Automation Scientist

About your company We have developed an improved Monocyte Activation Test (MAT) for pyrogen testing. The MAT serves as the replacement for the Rabbit Pyrogen Test and can be used […]

About your company

 
We have developed an improved Monocyte Activation Test (MAT) for pyrogen testing. The MAT serves as the replacement for the Rabbit Pyrogen Test and can be used to test parenteral drugs for endotoxin and non-endotoxin contaminations. Our technology uses cryopreserved pooled PBMC. This has made it possible to develop a MAT with both high sensitivity and robustness, ensuring reliability in the field.

Monocyte Activation Test (MAT)
The Monocyte Activation Test (MAT) is a pyrogen test. MAT uses human blood cells to test for a fever reaction, mimicking the human immune reaction. The MAT serves as the replacement for the Rabbit Pyrogen Test and can be used to test parenteral drugs for endotoxin and non-endotoxin contaminations. Our technology uses cryopreserved pooled PBMC. This has made it possible to develop a MAT with both high sensitivity and robustness, ensuring reliability in the field. The MAT kit includes all the required consumables to perform the Monocyte Activation Test, making it convenient to perform. In addition to the kit we provide consulting services and technical support in setting up the MAT in your organisation.

Job description

 
MAT Research is a pioneering company in the field of pyrogen testing, committed to ushering in a new era of ethical and accurate diagnostics. Since 2016, we have been leading the development of the Monocyte Activation Test (MAT), an animal-free alternative to traditional Rabbit Pyrogen Tests. Our ready-to-use MAT kits offer a robust and highly reliable method for detecting a broad range of pyrogens in parenteral drugs. ISO:9001:2015 certified, we uphold the highest standards of quality in all our products and services. By focusing on in-vitro human-based testing, we aim to drastically increase patient safety while saving hundreds of thousands of animal lives each year. We are steadfast supporters of the European Pharmacopoeia’s vision to replace animal-based tests with MAT by 2026. For more details, go to our job page.

We are looking for an exceptional Automation Scientist with a strong foundation in Immunology and Biotechnology. This pivotal role is designed for an individual passionate about leveraging automation to elevate the efficiency and quality of both our R&D and manufacturing landscapes.

Your key responsibilities will include:

• Strategic Automation Leadership: Formulate and implement strategies and tactics to enhance automation performance across the board.
• R&D and Manufacturing Automation: Spearhead automation initiatives within research and development, as well as manufacturing processes, to boost throughput and precision.
• AutoMATR System Management: From design and integration to maintenance, ensure the AutoMATR systems operate seamlessly and effectively.
• Documentation and Data Integrity: Uphold meticulous documentation practices and guarantee the accuracy and integrity of automation-generated data.

To fulfill these responsibilities, you will:

• Develop and optimize automation assays for MAT Research products, including ELISA.
• Facilitate the setup and troubleshooting of AutoMATR robotics at client sites.
• Conduct training sessions for both team members and clients, focusing on laboratory automation techniques.
• Revise and refine SOPs related to operations and automation.
• Troubleshoot robotics and instrumentation, ensuring efficient error recovery.
• Design integrated platforms for comprehensive automation of workflows.
• Innovate automated methods and data solutions to enhance productivity.
• Regularly maintain robotic platforms to ensure operational excellence.
• Contribute to cross-functional meetings with insightful presentations of results.
• Champion data integrity throughout automated processes.
• Explore and integrate advanced automation and assay strategies, incorporating AI and machine learning.
• Analyze and report data, employing computational tools as needed.
• Remain abreast of the latest trends and technologies in automation.

Job requirements

• Living in the Netherlands near Leiden or able to relocate in the short term.
• Proven experience with liquid handling systems.
• A Master’s degree and at least 2 years of post-graduate experience in Robotics, Biochemistry, Biotechnology, Automation, Biophysics, or a related field.
• Solid educational background in Immunology, Engineering, Automated Sciences, Computer Science, Biology, Chemistry, or a related field, with hands-on experience in assay development and execution.
• Expert-level skills in data analysis software and modern quality management systems.
• Proficient in generating, analyzing, and interpreting scientific data from robotic platforms.
• Skilled in mechanical troubleshooting, particularly with liquid handlers.
• Experienced in programming (R, Python) and script writing to automate tasks.
• Familiar with data science tools such as Python, R, SQL/no-SQL databases, AWS, Docker, etc.
• Innovative with an entrepreneurial attitude, looking beyond what is possible and known.
• Self-starter with teamwork skills, adept at juggling priorities to nail deadlines.
• Willing to hit the road for occasional business trips.
• Fluent in English
• proficiency in Dutch, German, or French is a major plus.
• Prior experience in a GMP/GLP and/or ISO 9001 environment is highly desirable.
• Hands-on experience in PBMC isolations, cellular assays, and analytical-based assays (ELISA, Flow Cytometry) according to regulatory standards such as ICH is an added advantage.

Your compensation will be:

• Competitive base salary (Full-time, 40 hrs/week)
• Twenty-five vacation days per year and your National Holidays off.

Link to vacancy

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