Helaas bent u niet ingelogd, login en probeer het opnieuw.    

PhD candidate in Quantitative Pharmacology of Antimicrobial Combination Therapie

The Faculty of Science and the Leiden Academic Centre for Drug Research (LACDR) are looking for a:
 

PhD candidate in Quantitative Pharmacology of Antimicrobial Combination Therapies (1.0 fte)

Vacancy number: 15471
 
We are looking for an ambitious PhD candidate to join our division Systems Pharmacology and Pharmacy, LACDR at Leiden University. The successful PhD applicant will perform innovative research in the field of quantitative antimicrobial pharmacology and pharmacometrics with a primary focus on design of innovative antimicrobial combination therapies.

 

Project description

Antimicrobial combinations are essential for combating antimicrobial resistance (AMR) and treating complex infections. However, selecting the right combinations and optimizing their dosing schedules to maximise efficacy and minimise the risk for AMR selection is challenging and requires extensive preclinical development. To streamline this process, there is an urgent need for standardised methodologies that integrate experimental assays and computational models. This PhD project, funded by JPIAMR, aims to develop a toolbox of experimental and pharmacometric approaches to improve the design and evaluation of antibiotic combination treatments.

 
We are seeking a PhD candidate with affinity to and experience in quantitative pharmacological modelling. In addition to developing pharmacometric models, the candidate would also contribute to the design and execution of complementary in vitro experiments, which will support the model development. This project will be conducted in close collaboration with academic partners at the University of Hamburg, the University of Poitiers, the University of Copenhagen, and University College London. 

 

Key responsibilities

• Conduct original, novel, and collaborative research in the framework of the project and complete your PhD thesis within 4 years;
• Publish scientific articles at international peer-review journals;
• Present at national and international conferences;
• Support education activities in the Bachelor’s and Master’s programs of Bio-Pharmaceutical Sciences and/or Pharmacy;
• Follow PhD courses based on an individual training and supervision plan.

 

Profile 

• A Master’s degree in a (bio-)pharmaceutical, biomedical sciences, pharmacy, or (quantitative) biology, or a similar master’s degree.
• Knowledge of PK/PD and (clinical) pharmacology
• Prior knowledge of infectious diseases, microbiology and antimicrobial pharmacology is desirable
• Hands-on experience with PK/PD modelling and/or mechanistic computational biological modelling
• Hands-on experience with using scientific scripting languages (R, Python)
• Hands-on laboratory experience, preferably in microbiological assays, or a strong interest to develop this experience during the PhD project
• Creative/out-of-the box thinker 
• Full proficiency in English (provide an IELTS/TOEFL score if available)
• Strong communication and writing skills
• Ability to work independently and in teams
• Excellent organisational and planning skills
• Interested in participating in educational tasks

 

Research at our faculty

Working at the Faculty of Science means being part of an exciting, dynamic scientific environment which sets high standards for its students and staff. The research carried out at the Faculty of Science is diverse, ranging from computer science, mathematics, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences.

 
The faculty has grown strongly in recent years and now has more than 2,300 staff and over 5,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together. For more information, see


.
 

Terms and conditions

We offer a full-time appointment of initially one year. After a positive evaluation of the progress of the research, teaching evaluations, personal capabilities and compatibility, the appointment will be extended for another three years. You will be appointed in accordance with the Collective Labour Agreement for Dutch Universities. The salary ranges from € 2.901,- per month in the first year to € 3.707,- gross per month in the fourth year based on a full-time position (pay scale P). 

 
Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. For international spouses we have set up a dual career program. Candidates from outside the Netherlands may be eligible for a substantial tax break. For more information, see the website:

.
 
All our PhD students are embedded in the Leiden University Graduate School of Science. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school.

 

Diversity and work-life balance

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups. LACDR is a highly diverse institute, in culture, background, and gender. We stand for excellence in a caring Institute. We wish to reflect society in all aspects, as we believe that this improves the dynamics in our organization. Therefore, we support and understand the need for a work/life/family balance and consequent varying working hours and places. We believe that doing good science is fun and goes hand in hand with a friendly culture.

 

More information

Enquiries can be made to Dr. Coen van Hasselt (

) or Dr. Linda Aulin (
l.b.s.aulin@lacdr.leidenuniv.nl
). If you have any questions about the procedure, please contact Ms. Mingmin Gong (
m.gong@lacdr.leidenuniv.nl
).
 

Applications

To apply for this vacancy, please submit your application online via the blue button below. Please ensure that you upload the following additional documents (in pdf format) quoting the vacancy number:

 
 

• Curriculum vitae
• Motivation letter (maximum one page), explaining how your experience and interests match with this PhD project.
• Contact information of at least three potential references, including your previous supervisor(s)

 
Only applications received before
14 March 2025
can be considered.

Location:
Leiden

FTE min:
1,0

FTE max:
1,0

Minimum Salary:
€2901,-

Maximum salary:
€3707,-

Job type:
Job openings for PhD
Apply now »

Find similar jobs:
Alle vacatures,
All jobs
Working at
Privacy statement
Cookies
×

Cookie Consent Manager

When you visit any website, it may store or retrieve information on your browser, mostly in the form of cookies. Because we respect your right to privacy, you can choose not to allow some types of cookies. However, blocking some types of cookies may impact your experience of the site and the services we are able to offer.

Required Cookies

These cookies are required to use this website and can't be turned off.
Show More Details
Required Cookies
Provider
Description
Enabled
SAP as service provider

We use the following session cookies, which are all required to enable the website to function:

• "route" is used for session stickiness
• "careerSiteCompanyId" is used to send the request to the correct data center
• "JSESSIONID" is placed on the visitor's device during the session so the server can identify the visitor
• "Load balancer cookie" (actual cookie name may vary) prevents a visitor from bouncing from one instance to another

meer...

Naar vacature

Meer vacatures van Universiteit Leiden

Postdoc - Translational Pharmacology in antibiotic r...

The Faculty of Science and the Leiden Academic Centre for Drug Research are looking for a: Postdoc – Translational Pharmacology in antibiotic regimen development Vacancynumber: 14993 The Division of Systems Pharmacology
21 uur geleden- Volledige vacature bekijken

2 PhD Candidates to study transcription factor bindi...

The Faculty of Science, the Leiden Institute of Physics (LION) and the Netherlands Cancer Institute (NKI) and are looking for:2 PhD Candidates to study transcription factor binding at the single-molecule level Precise
1 dag geleden- Volledige vacature bekijken

PhD Candidate in the Field of Supramolecular Biomate...

The Faculty of Science Leiden and Leiden Institute of Chemistry, SBC department are looking for a PhD candidate in the field of supramolecular biomaterialsWork and profile The biochemical and biophysical cues of the stem
5 dagen geleden- Volledige vacature bekijken

PhD candidate combinatorial drug discovery with macr...

Offer Terms and conditionsWe offer a full-time appointment of initially one year. After a positive evaluation of the progress of the research, teaching evaluations, personal capabilities and
1 dag geleden- Volledige vacature bekijken